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产品目录

所在位置:所有产品 > 抗体抗原 > 一抗 > PUMA/BBC3抗体
PUMA/BBC3抗体图片
产品货号:
Z24569
中文名称:
PUMA/BBC3抗体
英文名称:
Anti-PUMA/BBC3 Antibody
产品规格:
0.1mg
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PUMA/BBC3 Antibody
指标别名BBC3;JFY 1;JFY1;PUMA
克隆性Polyclonal
检验物种human,mouse
应用范围ELISA,WB,ICC,IF
基因名称BBC3
抗体来源Rabbit
抗体类型IgG
免疫原Anti-PUMA antibody was raised against a peptide corresponding to 14 amino acids near the carboxyl terminus human PUMA isoform 1.The immunogen is located within the last 50 amino acids of PUMA.
计算分子量26kDa
成分PUMA Antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式PUMA Antibody is affinity chromatography purified via peptide column.
浓度1mg/mL
产品形态溶液
保存条件4℃可保存3个月,-20℃可保存1年。
背景资料Apoptosis is related to many diseases and development.The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes.A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse.PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa,which are also transcriptional targets of p53 (1).The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (2).PUMA proteins bind Bcl-2,localize to the mitochondria,and induce cytochrome c release and apoptosis in response to p53.PUMA may be a direct mediator of p53-induced apoptosis.
Uniprot IDQ96PG8
基因名全称BCL2 binding component 3
蛋白名全称BCL2 binding component 3
推荐稀释比WB:1~4μg/mL;IF:2μg/mL;ICC:1μg/mL.Antibody validated:Western Blot in human and mouse samples;Immunocytochemistry and Immunofluorescence in human samples.All other applications and species not yet tested.

相关搜索:PUMA/BBC3抗体PUMA抗体BBC3多抗Anti-PUMA/BBC3 Antibody
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